SMTP bounce code 5.2.2 indicates that the recipient's mailbox has exceeded its storage quota and the condition is considered permanent. Unlike the temporary 4.2.2 bounce, this code suggests the mailbox is unlikely to be cleared and should be treated as a hard bounce.
The enhanced status code 5.2.2 follows the SMTP Enhanced Status Code format:
5 = Permanent failure (hard bounce)
2 = Mailbox status (related to the recipient's mailbox)
2 = Mailbox full (permanent condition)
When you receive a 5.2.2 bounce, it means the recipient's mailbox has been full for an extended period and the email provider has determined it's unlikely to be cleared. This is treated as a permanent failure, similar to other hard bounces.
4.2.2 (Temporary): Mailbox is full but may be cleared—retry sending
5.2.2 (Permanent): Mailbox has been full for an extended period—remove from list
The key difference is that 4.2.2 suggests the condition is temporary and may resolve, while 5.2.2 indicates the condition is permanent and unlikely to change.